"Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects. "
Michael S. Irwig, MD. Journal of Clinical Psychiatry, 2012 DOI: 10.4088/JCP.12m07887
Michael S. Irwig, MD. Journal of Clinical Psychiatry, 2012 DOI: 10.4088/JCP.12m07887
CNS Drug Rev. 2006 Spring;12(1):53-76.
http://www.propeciahelp.com/forum/viewtopic.php?f=8&t=202
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"5alpha-reductase inhibitors and erectile dysfunction: Connection" (2008 study):
Erdemir F, Harbin A, Hellstrom WJ.
http :/ / www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=19090946
Finasteride induced depression:
In the study, a controlled group of 128 men, with a daily dose of 1mg per day, had clear and significant increase in depression, verified by BDI and HADS in patients taking finasteride.
Rahimi-Ardabili B, R Pourandarjani, Habibollahi P Mualeki A (2006).
"Finasteride induced depression: a prospective study"
http://www.ncbi.nlm.nih.gov/pubmed/17026771
Finasteride robustly increases anxiety and depression in animals:
Römer B , Gass P (December 2010). "Finasteride-induced depression: new insights into possible pathomechanisms." Journal of Cosmetic Dermatology
http://www.ncbi.nlm.nih.gov/pubmed/21122055
Depression associated to the use of Finasteride
In this study, using 1mg dosage, Finasteride induced moderate to severe depression in 19 of the 23 participants, or 83%, including notably, all female subjects. University of Milan: http://www.ncbi.nlm.nih.gov/pubmed/12433001?dopt=Abstract
"Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients"
Published on December 2010 on The Journal of Sexual Medicine
http://onlinelibrary.wiley.com/doi/10.1111/j.1743-6109.2010.02157.x/abstract
Authors:
Abdulmaged M. Traish PhD
Dr. Andre T. Guay MD
Dr. D Michael Zitzmann, PhD
Dr. John Hassani MA.
Michael L. Hansen MD
"Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss."
Published by Dr. Michael S. Irwig, University George Washington.
This study evaluated 71 men between 21 and 46, who complained of sexual effects that did not improve even after the treatment with finasteride was discontinued. According to the authors of the study, published in "Journal of Sexual Medicine," the side effects persisted for 40 months after stopping treatment, on average. Impotence and loss of libido were observed until six years after use, in a fifth of respondents . "Finasteride and Neuroactive Steroids."
The study concluded that there was a drastic reduction of neuro active steroids after a period of four months, with controlled groups that used doses of Finasteride 1mg and 5 mg. Observe the decrease in allopregnanolone (-303.1%).
Published in Prague Medical Report m 2009 (Vol. 110)
Study indicates finasteride inhibits the conversion of hormones into neurosteroids in the brain. These neurosteroids have antidepressant, antianxiety and anticonvulsive effects.
Among them Allopregnanolone and Tetrahydrodeoxycorticosterone.
"A new vision on Finasteride"
Department of veterans, Portland, USA.
http://www.ncbi.nlm.nih.gov / pubmed/16834758? Dopt = Abstract
Male infertility associated with the use of finasteride.
Study of the human reproduction unit, Albert Einstein Hospital, Sao Paulo -
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812004000400009&tlng=es&lng=en&nrm=iso
Links of various studies relating finasteride use to infertility, sperm motility problems and fail in spermatogenesis:
http://www.propeciahelp.com/forum/viewtopic.php?f=8&t=245
Study with photographic evidence that the shrinkage of the prostate induced by finasteride is caused through cell death (apoptosis).
Dalhousie University, Halifax, Canada:
http://jcem.endojournals.org/content/81/2/814.abstract
Study proves that finasteride alters levels of testosterone, DHT, hormone luteinizing, follicle stimulating hormone.
Uroclínica from the Health Ministry, Ankara, Turkey:
http://www.ncbi.nlm.nih.gov/pubmed/9589555?dopt=Abstract
Finasteride alters cholesterol levels after 6 months of treatment.
University of Parma,
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=10996351&dopt=Citation
Chemical castration effect related to the use of finasteride.
Chart of the American Environmental Agency EPA
http://www.epa.gov/comptox/bosc_review/2006/files/posters/17_Barton.pdf
Links to various studies about finasteride, both 1mg and 5mg:
http://www.propeciahelp.com/forum/viewforum.php?f=8&sid=511e2201fa63bd8c5ee8ad81f4ca7e4b
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